Ammonia → RO-05-2921

HRID 1734324

Reaktionsgleichung

Reaktionsgleichung von HRID 1734324
Br[CH2:2][C:3]([NH:5][C:6]1[CH:19]=[CH:18][CH:17]=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O)=[O:4].[NH3:20].O>CO>[C:10]1([C:8]2[C:7]3[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=3[NH:5][C:3](=[O:4])[CH2:2][N:20]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 84439N-(2-Benzoylphenyl)-2-bromoacetamide

Produkt 1

HCID 76175RO-05-2921Ausbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

A suspension of 2-bromoacetamidobenzophenone (275 g, 0.86 mol) in methanol (1 L) was treated with a solution of saturated ammonia in methanol (3 L), and the resulting solution was stirred at ambient temperature for 6 h, then was heated at reflux for an additional 4 h. After cooling, water (500 mL) was added, and the solution was concentrated by evaporation to about 1 L in volume, yielding crystalline 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (20) (200.7 g, 98%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for an additional 4 h
  3. temperatureAfter cooling
  4. concentrationthe solution was concentrated by evaporation to about 1 L in volume

Quellen und Nachweise

ORD-Eintrag
ord-a0826e8108a34c36a4b1e6d5676bbd6a
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05532359

Verknüpfte Notizen

Wird geladen…