Potassium thiocyanate → 3-Methyl-4-thiocyanato-5-aminoisothiazole

HRID 1735689Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1735689
[CH3:1][C:2]1[C:6](Br)=[C:5]([NH2:8])[S:4][N:3]=1.[C:9]([S-:11])#[N:10].[K+]>CO>[CH3:1][C:2]1[C:6]([S:11][C:9]#[N:10])=[C:5]([NH2:8])[S:4][N:3]=1

Komponenten

4

Edukt 2

HCID 516872Potassium thiocyanateHCID 177499314-Bromo-3-methyl-1,2-thiazol-5-amine

Produkt 1

HCID 146188853-Methyl-4-thiocyanato-5-aminoisothiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

386 g of 3-methyl-4-bromo-5-aminoisothiazole and 200 g of KSCN in methanol are refluxed for 6 hours. The product crystallizes out on cooling. 800 ml of water are added and the product is filtered off under suction and washed with water.

Aufarbeitung

  1. customThe product crystallizes out
  2. temperatureon cooling
  3. addition800 ml of water are added
  4. filtrationthe product is filtered off under suction
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-7f6a56f2abef48c7b73daed48f3895b6
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05538939

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