Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 1736647

Reaktionsgleichung

Reaktionsgleichung von HRID 1736647
[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Komponenten

5

Edukt 4

HCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 68114Atropic acid

Produkt 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamideAusbeute 28,9 %

Versuchsvorschrift

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate (9.2 ml, 70.9 mmol), and cyclohexylamine (8.1 ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131°-133°.

Aufarbeitung

  1. customThe crude product was purified by recrystallisation from cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-c6ee4328a78b4152bb6aebc83b354bc5
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05541326

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