tert-Butylacetic acid → HCID 178442262, Verbindung

HRID 1737150Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1737150
[CH:1]1[CH:2]=[CH:3][C:4]2[C:11](=[O:12])[C:10]([OH:13])=[CH:9][C:7](=[O:8])[C:5]=2[CH:6]=1.[CH3:14][C:15]([CH3:21])([CH3:20])[CH2:16]C(O)=O.S(O[O-])([O-])(=O)=O.[NH4+].[NH4+]>C(#N)C.O.[N+]([O-])([O-])=O.[Ag+]>[CH3:14][C:15]([CH3:21])([CH3:20])[CH2:16][C:9]1[C:7](=[O:8])[C:5]2[C:4]([C:11](=[O:12])[C:10]=1[OH:13])=[CH:3][CH:2]=[CH:1][CH:6]=2

Komponenten

7

Edukt 3

HCID 14057tert-Butylacetic acidHCID 9855511Ammonium peroxysulphateHCID 178516607HCID 178516607, Verbindung

Produkt 1

HCID 178442262HCID 178442262, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 24470Silver NitrateKatalysatorHCID 962WaterLösungsmittel2×HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

This compound was prepared by the general methods as described in Examples 1 to 15. Lawsone (0.15 g), 3,3-dimethylbutyric acid (0.15 g), and silver nitrate (0.15 g) were heated in a mixture of acetonitrile (5 ml) and water (5 ml) at 60-65° C. A solution of ammonium peroxysulphate (0.3 g) in water (5 ml) was added dropwise and the mixture heated for 1 hour and then processed as for Example 3 to yield the title compound . The crude product was purified on a silica gel column using 20% diethyl ether in petroleum ether eluant and recrystallised from petroleum ether to yield 38 mg of the title compound.

Aufarbeitung

  1. customThis compound was prepared by the general methods
  2. temperaturethe mixture heated for 1 hour

Quellen und Nachweise

ORD-Eintrag
ord-7b53e09bc124424688b926d1dac1b8a3
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05962002

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