Hydrochloric Acid → HCID 178418437, Verbindung

HRID 1737935

Reaktionsgleichung

Reaktionsgleichung von HRID 1737935
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH3:27])[CH3:26])=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:10])=[CH:4][CH:3]=1.Cl>C(OCC)C.C(O)(C)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][C@H:12]2[CH2:13][CH2:14][C@H:15]([C:18]3[CH:19]=[CH:20][C:21]([CH2:24][N:25]([CH3:26])[CH3:27])=[CH:22][CH:23]=3)[CH2:16][CH2:17]2)=[O:10])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 178418347HCID 178418347, Verbindung

Produkt 1

HCID 178418437HCID 178418437, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol in 10 ml of diethyl ether is combined at ambient temperature, with stirring, with a 1.5 times equimolar amount of hydrogen chloride in isopropanol added dropwise. The precipitate formed is left for 1 hour at ambient temperature, suction filtered, washed repeatedly with diethyl ether and dried. White crystals are obtained, melting point 231-233° C. Yield: 0.32 g (76% of theory). C23H29Cl2NO2 (422.40) Calculated: C 65.40 H 6.92 N 3.32 Cl 16.79 Found: 65.33 7.06 3.45 16.92

Aufarbeitung

  1. customis combined at ambient temperature
  2. additionadded dropwise
  3. customThe precipitate formed
  4. filtrationsuction filtered
  5. washwashed repeatedly with diethyl ether
  6. customdried
  7. customWhite crystals are obtained

Quellen und Nachweise

ORD-Eintrag
ord-73b2da3a71ba4351a5701078dc2ad8c9
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05962507

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