Valeryl chloride → Benzyl(S)-2-((2'-cyanobiphenyl-4-ylmethyl)pentanoylamino)-3-methylbutyrate
Reaktionsgleichung
Cl.[CH2:2]([O:9][C:10](=[O:31])[C@H:11]([CH:28]([CH3:30])[CH3:29])[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:16][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(C(C)C)CC)(C)C.[C:41](Cl)(=[O:46])[CH2:42][CH2:43][CH2:44][CH3:45]>>[CH2:2]([O:9][C:10](=[O:31])[C@H:11]([CH:28]([CH3:29])[CH3:30])[N:12]([C:41](=[O:46])[CH2:42][CH2:43][CH2:44][CH3:45])[CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:18][CH:19]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1Komponenten
4
Versuchsvorschrift
5.5 g of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine benzyl ester hydrochloride, 4.33 g of diisopropylethylamine and 3 ml of valeryl chloride are stirred at room temperature for 36 hours and the mixture is then evaporated to dryness. The residue is taken up in ether and washed with sodium bicarbonate and brine. The crude product is further processed without purification.