Hydrazine hydrate (1:1) → 2-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

HRID 1739429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1739429
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:8]([C:13](=O)[C:14]2[CH:19]=[CH:18][N:17]=[C:16]([Br:20])[CH:15]=2)=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.O.[NH2:23][NH2:24]>CO>[Br:20][C:16]1[CH:15]=[C:14]([C:13]2[C:8]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:10]([O:11][CH3:12])[CH:9]=3)[CH:6]=[N:24][N:23]=2)[CH:19]=[CH:18][N:17]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 218408403,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde

Produkt 1

HCID 218408262-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (4.5 g) in methanol (70 ml) is added dropwise hydrazine monohydrate (0.8 ml). The reaction mixture is cooled with ice, and the precipitates are collected by filtration, and recrystallized from methanol to give 2-bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine (4.01 g) as yellow crystals.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled with ice
  2. filtrationthe precipitates are collected by filtration
  3. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-daa5282d355343339542882c9bf68cc2
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05965730

Notizen zur Reaktion

Wird geladen…