1,1,3-Trichloroacetone → CID 6037

HRID 1739630

Reaktionsgleichung

Reaktionsgleichung von HRID 1739630
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[C:4]([OH:10])[N:3]=1.Cl[CH:12](Cl)[C:13]([CH2:15]Cl)=O.[NH2:18][C:19]1[CH:36]=[CH:35][C:22]([C:23]([NH:25][C@H:26]([C:32]([OH:34])=[O:33])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:24])=[CH:21][CH:20]=1.N([O-])=O.[Na+].C([O-])(=O)C.[Na+]>>[CH:21]1[C:22]([C:23]([NH:25][C@H:26]([C:32]([OH:34])=[O:33])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:24])=[CH:35][CH:36]=[C:19]([NH:18][CH2:15][C:13]2[N:9]=[C:5]3[C:4]([N:3]=[C:2]([NH2:1])[NH:7][C:6]3=[N:8][CH:12]=2)=[O:10])[CH:20]=1

Komponenten

6

Edukt 5

HCID 135301,1,3-TrichloroacetoneHCID 196473N-(4-Aminobenzoyl)-L-glutamic acidHCID 517045Sodium AcetateHCID 23668193Sodium NitriteHCID 178508811HCID 178508811, Verbindung

Produkt 1

HCID 6037CID 6037

Versuchsvorschrift

At present, PteGlu of folic acids is industrially produced through chemical synthesis. Briefly, three components of 2,4,5-triamino-6-hydroxypyrimidine, 1,1,3-trichloroacetone and p-aminobenzoylglutamic acid are condensed in the presence of sodium nitrite in a solution of sodium acetate to give a crude product of folic acid, PteGlu, and the product is purified through recrystallization.

Quellen und Nachweise

ORD-Eintrag
ord-a3e409f1a2884e0ca66da9fbec0fafc4
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05968788

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