Ethyl benzoylformate → N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide

HRID 1739810

Reaktionsgleichung

Reaktionsgleichung von HRID 1739810
[C:1]1([C:7](=[O:13])[C:8]([O:10]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:17][CH2:16]1>C(O)C>[CH2:21]([N:18]1[CH2:19][CH2:20][CH:15]([NH:14][C:8](=[O:10])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:13])[CH2:16][CH2:17]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Komponenten

4

Edukt 2

HCID 15349Ethyl benzoylformateHCID 4158521-Benzyl-4-piperidylamine

Produkt 1

HCID 11120838N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amideAusbeute 81,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

Added to 4.28 g of ethyl phenylglyoxylate were 9.12 g of 4-amino-1-benzylpiperidine. The mixture was heated and stirred at 120° C. for 3 hours on an oil bath. Thereafter, ethanol formed was distilled off under reduced pressure, and the residue was purified by column chromatography on silica gel, thereby obtaining 6.3 g (yield: 81.4%) of N- (1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. distillationwas distilled off under reduced pressure
  3. customthe residue was purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-8f477e3b0b734482a249820ee94a5696
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05968956

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