Ethanol → 1-(4-Cyanophenyl)-4-hydroxycarbonyl-2-methyl-3-[4-(2-pyridyl)phenyl]-2H-pyrazol-5-one

HRID 1740085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1740085
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13](=[O:14])[C:12]([C:15]([O:17]CC)=[O:16])=[C:11]([C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:22][CH:21]=3)[N:10]2[CH3:32])=[CH:5][CH:4]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].C(O)C>O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13](=[O:14])[C:12]([C:15]([OH:17])=[O:16])=[C:11]([C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:22][CH:21]=3)[N:10]2[CH3:32])=[CH:7][CH:8]=1)#[N:2]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 11430Potassium CarbonateHCID 218376381-(4-cyanophenyl)-4-ethoxycarbonyl-2-methyl-3-[4-(2-pyridyl)phenyl]-2H-pyrazol-5-one

Produkt 1

HCID 218376341-(4-Cyanophenyl)-4-hydroxycarbonyl-2-methyl-3-[4-(2-pyridyl)phenyl]-2H-pyrazol-5-oneAusbeute 63,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2.7 g of 1-(4-cyanophenyl)-4-ethoxycarbonyl-2-methyl-3-[4-(2-pyridyl)phenyl]-2H-pyrazol-5-one, 1.8 g of potassium carbonate, 73 ml of ethanol and 8 ml of water was refluxed under heating for 9 hours. The reaction solution was cooled to room temperature, and the precipitated crystals were collected by filtration and dried under reduced pressure. The resulting crude crystals were suspended in chloroform, and the suspension was adjusted to pH 2 to 3 with dilute hydrochloric acid. The crystals were collected by filtration and dried under reduced pressure to give 1.6 g of the title compound as pale gray crystals.

Aufarbeitung

  1. temperaturewas refluxed
  2. temperatureunder heating for 9 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. customdried under reduced pressure
  5. filtrationThe crystals were collected by filtration
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d4ba679ec8e644109add6a8d10145440
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05968967

Notizen zur Reaktion

Wird geladen…