Sodium Chloride → Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-

HRID 1741227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1741227
[N:1]([C:10]([CH3:16])([CH3:15])[C:11]([O:13]C)=O)=[N:2][C:3]([CH3:9])([CH3:8])[C:4]([O:6]C)=O.[NH2:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23].[CH3:24][O:25][Na].[Cl-].[Na+]>CO>[N:2]([C:3]([CH3:8])([CH3:9])[C:4]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:24][OH:25])=[O:6])=[N:1][C:10]([CH3:16])([CH3:15])[C:11]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])=[O:13]

Komponenten

6

Edukt 4

HCID 5234Sodium ChlorideHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 757631,1'-Dimethyl 2,2'-(1,2-diazenediyl)bis(2-methylpropanoate)HCID 178418582HCID 178418582, Verbindung

Produkt 1

HCID 54254381Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-Ausbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a constantly stirred mixture comprising 23.0 g of V-601, 22.9 g of 2-(2-aminoethylamino)ethanol and 5 ml of methanol, 4.7 g of 28% CH3ONa was added dropwise. The reaction was carried out with stirring at room temperature for 8 hours. After standing overnight, the reaction mixture was mixed with 50 ml of saturated sodium chloride solution, and extracted with 100 ml of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and solvent was distilled off, and there was obtained 29.8 g (yield 80%) of 2,2'-azobis [N-(2-hydroxyethylamino)ethyl-2-methylpropionamide ] of yellow viscous liquid.

Aufarbeitung

  1. additionwas added dropwise
  2. waitAfter standing overnight
  3. extractionextracted with 100 ml of dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate and solvent
  5. distillationwas distilled off

Quellen und Nachweise

ORD-Eintrag
ord-03b016fd021244409625e482f549bfb5
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05973125

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