Pyridine → N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

HRID 1741263

Reaktionsgleichung

Reaktionsgleichung von HRID 1741263
[CH3:1][S:2][CH3:3].ClCl.[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[CH:9][C:8]=1[Br:13].N1C=CC=CC=1>ClCCl>[Br:13][C:8]1[CH:9]=[N:10][N:11]([CH3:12])[C:7]=1[N:6]=[S:2]([CH3:3])[CH3:1]

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 1068Dimethyl SulfideHCID 24526ChlorineHCID 6003514-Bromo-1-methyl-1H-pyrazol-5-amine

Produkt 1

HCID 23303942N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 0.60 mL (8.2 mmol) of dimethyl sulfide in 30 mL of dichloromethane was cooled to -20° C. and 0.50 g (7.0 mmol) of chlorine was added through a sparge tube with cooling and stirring. Subsequently, 1.0 g (5.7 mmol) of 5-amino-4-bromo-l-methylpyrazole and then 1.0 g (12.7 mmol) of pyridine were added with cooling and stirring. A 2 mL aliquot of this mixture was removed and the light yellow solids present were collected by filtration and washed with deuteroacetonitrile.

Aufarbeitung

  1. temperaturewith cooling
  2. temperaturewith cooling
  3. stirringstirring
  4. customA 2 mL aliquot of this mixture was removed
  5. filtrationthe light yellow solids present were collected by filtration
  6. washwashed with deuteroacetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-a70216e9faf0426ea55ddb0fffc328a2
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05973148

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