Formaldehyde → HCID 21834627, Verbindung

HRID 1741473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1741473
[CH2:1]([NH:8][CH2:9][CH2:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C=O.[C:26]([BH3-])#N.[Na+]>CC#N.O>[CH2:1]([N:8]([CH2:9][CH2:10][CH:11]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:26])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 8032053HCID 8032053, Verbindung

Produkt 1

HCID 21834627HCID 21834627, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 18373917Acetonitrile--water (1/1)Lösungsmittel

Versuchsvorschrift

To a solution of N-benzyl-3,3-diphenylpropylamine (1.29 g, 4.30 mmol) and 30% aq. formaldehyde (1.50 ml, 20 mmol) in CH3CN:H2O (2:1, v/v, 40 ml) was added sodium cyanoborohydride (563 mg, 8.96 mmol) at 0° C. The reaction was allowed to warm to room temperature and stirred for 90 min. The organic solvent was evaporated, and the residue diluted with water and extracted with CH2Cl2. The organic extracts were washed with brine, dried (Na2SO4) and the solvent evaporated in vacuo to afford the title compound as an oil.

Aufarbeitung

  1. customThe organic solvent was evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with CH2Cl2
  4. washThe organic extracts were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customthe solvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f68a81e662ee4b109caab7ff4a1b3354
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05972984

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