Triethylamine → HCID 18660145, Verbindung

HRID 1741481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1741481
[OH:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:12])([F:11])[F:10].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[CH3:21][S:22]([O:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:10])([F:11])[F:12])(=[O:24])=[O:23]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

Produkt 1

HCID 18660145HCID 18660145, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of the product of step A (1.002 g, 5.08 mmol) and triethylamine (0.78 ml, 5.60 mmol) in CH2Cl2 (50 ml) at -25° C. was added methane sulfonyl chloride (0.40 ml, 5.17 mmol) over a period of 5 min and stirring was continued for 1 hr. The solvent was evaporated in vacuo and the residue purified by chromatography(SiO2, 33% EtOAc in hexanes, elution). The title compound was obtained as a colorless oil.

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by chromatography(SiO2, 33% EtOAc in hexanes, elution)

Quellen und Nachweise

ORD-Eintrag
ord-f35831bc33844711b55c5bae2d3545ed
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05972984

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