3,4-dihydro-2H-pyran → 3-Butyryl-1,2-benzisoxazole

HRID 1742543

Reaktionsgleichung

Reaktionsgleichung von HRID 1742543
[C:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)([OH:3])=O.[CH2:13]([CH:15](C(O)=O)C(O)=O)[CH3:14].O1C=CCCC1>>[C:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)(=[O:3])[CH2:14][CH2:13][CH3:15]

Komponenten

4

Edukt 3

HCID 80803,4-dihydro-2H-pyranHCID 11756Ethylmalonic acidHCID 27354451,2-Benzoxazole-3-carboxylic acid

Produkt 1

HCID 199769213-Butyryl-1,2-benzisoxazole

Versuchsvorschrift

Using 3.7 g (23 retool) of 3-carboxy-1,2-benzisoxazole prepared in accordance with a known process [J. Amer. Chem. Soc., 97, 7305 (1975)], 3.34 g (25 mmol) of ethylmalonic acid and 6.4 g of 3,4-dihydropyran, 3-butyryl-1,2-benzisoxazole was obtained as colorless crystals by similar treatment to Example 28-(4). Analytical results of the crystals obtained: Yield: 3.5 g (85%). Melting point: 33°-35° C.

Quellen und Nachweise

ORD-Eintrag
ord-7888a99fe8564a4bb023dfcb1233dc99
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05338857

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