Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 1742598

Reaktionsgleichung

Reaktionsgleichung von HRID 1742598
[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Komponenten

5

Edukt 4

HCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 68114Atropic acid

Produkt 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamideAusbeute 28,9 %

Versuchsvorschrift

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate (9.2 ml, 70.9 mmol), and cyclohexylamine (8.1 ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131°-133°.

Aufarbeitung

  1. customThe crude product was purified by recrystallisation from cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-7b62bea8052343679696fa051021d1ca
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05340812

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