Sodium Hydroxide → (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide
Reaktionsgleichung
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[C:11]([C:14]([C@@H:27]1[CH2:31][CH2:30][NH:29][CH2:28]1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:13])[NH2:12].[OH-].[Na+]>O>[C:11]([C:14]([C@@H:27]1[CH2:31][CH2:30][NH:29][CH2:28]1)([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:13])[NH2:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine L-(+)-tartrate from part (A) (0.95 g) was dissolved in water (40 ml) and basified (pH 12) by the dropwise addition of 10% aqueous sodium hydroxide. The mixture was extracted with dichloromethane (2×50 ml), the extracts were combined, dried (Na2SO4), and concentrated in vacuo to give the title compound as a colourless foam, yield 0.64 g.