Sodium Carbonate → 4-(2-Bromoethyl)-1,2-dimethylbenzene

HRID 1742711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1742711
P(Br)(Br)[Br:2].[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10]O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)(Cl)Cl.O>[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10][Br:2]

Komponenten

6

Edukt 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 339432-(3,4-Dimethylphenyl)ethanol

Produkt 1

HCID 225073204-(2-Bromoethyl)-1,2-dimethylbenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

Phosphorus tribromide (0.82 g) was added dropwise to a solution of 3,4-dimethylphenethyl alcohol (1.27 g--see Preparation 17) in carbon tetrachloride (10 ml). The mixture was heated under reflux for 2.5 hours then cooled to room temperature and basified (pit 8) by the dropwise addition of 10% aqueous sodium carbonate (5 ml). The mixture was then diluted with water (20 ml) and extracted with dichloromethane (3×50 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a colourless oil, yield, 0.5g.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 2.5 hours
  3. extractionextracted with dichloromethane (3×50 ml)
  4. dry with materialThe combined dichloromethane extracts were dried (MgSO4)
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-908ce39a84834261a6c3f1b81c199a4a
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05340831

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