Sodium Dithionite → 5,6-Diamino-1,3-dicyclopropyluracil

HRID 1742808

Reaktionsgleichung

Reaktionsgleichung von HRID 1742808
[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[N:5]([CH:12]2[CH2:14][CH2:13]2)[C:4](=[O:15])[C:3]=1[N:16]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+].NC1N(CC2CC2)C(=O)N(CC2CC2)C(=O)C=1.N([O-])=O.[Na+]>>[NH2:16][C:3]1[C:4](=[O:15])[N:5]([CH:12]2[CH2:14][CH2:13]2)[C:6](=[O:11])[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:2]=1[NH2:1]

Komponenten

5

Edukt 4

HCID 24489Sodium DithioniteHCID 186245156-Amino-1,3-bis(cyclopropylmethyl)uracilHCID 190058846-Amino-1,3-dicyclopropyl-5-nitrosouracilHCID 23668193Sodium Nitrite

Produkt 1

HCID 190058885,6-Diamino-1,3-dicyclopropyluracilAusbeute 84,9 %

Versuchsvorschrift

The procedure similar to that described in Reference Example 1 was repeated except that 1.55 g (6.57 mmol) of Compound g prepared above and 2.86 g (16.4 mmol) of sodium hydrosulfite were employed in place of 6-amino-1,3-bis(cyclopropylmethyl)uracil and sodium nitrite, respectively. As a result, 1.24 g (yield: 75%) of Compound d was obtained as white powder.

Quellen und Nachweise

ORD-Eintrag
ord-7f19b1ecd37541a5b447b5dec28647c5
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05342841

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