Diethyl Ether → 1-(4-Pyridyl)-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene

1-(4-Pyridyl)- 2,3-bis(methoxycarbonyl)-6,7-dimethoxy-1,4-epoxy-1,4-dihydronaphthalene (3.0 g) and trifluoroborane.diethyl ether (1.95 g) are added to acetonitrile (100 ml), and the mixture is refluxed for 2 hours. The reaction solution is separated with a mixture of chloroform (300 ml) and aqueous sodium hydrogen carbonate solution (50 ml), and the organic layer is further washed with aqueous sodium hydrogen carbonate solution, dried, and concentrated. The resulting residue is washed with a small amount of diethyl ether to give 1-(4-pyridyl)-2,3-bis(methoxy-carbonyl)-6,7-dimethoxynaphthalene (2.1 g) as crystal.

1. temperaturethe mixture is refluxed for 2 hours
2. customThe reaction solution is separated with a mixture of chloroform (300 ml) and aqueous sodium hydrogen carbonate solution (50 ml)
3. washthe organic layer is further washed with aqueous sodium hydrogen carbonate solution
4. customdried
5. concentrationconcentrated
6. washThe resulting residue is washed with a small amount of diethyl ether

ORD-Eintrag

ord-1ac07c276e6c413681a20eb07e24fb5f

Quelldatensatz

uspto-grants-1994_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05342941