Hydrochloric Acid → HCID 28354564, Verbindung

HRID 1744057Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744057
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[Li+].[OH-].Cl>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:9]([OH:11])=[O:10])=[CH:17][CH:18]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86594553HCID 86594553, Verbindung

Produkt 1

HCID 28354564HCID 28354564, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To methyl (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoate (2.198 g, 7.0 mmol) in MeOH (30 mL) was added an aqueous solution of LiOH (2 M, 17.5 mL, 35 mmol) and the reaction was stirred overnight. The reaction was neutralized with aqueous 10% HCl (pH of 6–7) and the product crystallized out of solution and was filtered and dried in vacuo to afford (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoic acid.

Aufarbeitung

  1. customthe product crystallized out of solution
  2. filtrationwas filtered
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-27630d94e7314f20af4009d83d8fa504
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07012075B2

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