Sodium Hydroxide → 1-(4-Fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

HRID 1744477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744477
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]([CH3:18])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]([CH3:18])=[N:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 22227950Ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 222280661-(4-Fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acidAusbeute 78,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Ethyl 1-(4-fluorophenyl)-3-methylpyrazole-5-carboxylate (2 g) was dissolved in a mixed solvent of ethanol (10 ml) and water (10 ml) and sodium hydroxide (0.4 g) was added. The mixture was stirred at a refluxing temperature for 30 min. Ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (1.4 g), melting point: 188° C.

Aufarbeitung

  1. additionwas added
  2. customEthanol was evaporated and to the residue
  3. additionwas added dilute hydrochloric acid
  4. customThe obtained solid was recrystallized from aqueous methanol solution

Quellen und Nachweise

ORD-Eintrag
ord-c6b18735a6df46afaf111fe7dabe6717
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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