Sodium Hydroxide → 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid

HRID 1744481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744481
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([O:15]C)=[O:14])=[N:3]1.[OH-].[Na+]>C(O)C.O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([OH:15])=[O:14])=[N:3]1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 21766260Methyl 1-methyl-5-phenyl-1h-pyrazole-3-carboxylate

Produkt 1

HCID 75376191-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acidAusbeute 65,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Methyl 1-methyl-5-phenylpyrazole-3-carboxylate (3.6 g) was dissolved in a mixed solvent of ethanol (20 ml) and water (20 ml) and sodium hydroxide (0.8 g) was added. The mixture was stirred at a refluxing temperature for 30 min. Ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (2.2 g), melting point: 149–150° C.

Aufarbeitung

  1. additionwas added
  2. customEthanol was evaporated and to the residue
  3. additionwas added dilute hydrochloric acid
  4. customThe obtained solid was recrystallized from aqueous methanol solution

Quellen und Nachweise

ORD-Eintrag
ord-738d63e9dd764f438106eba37cc859f0
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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