1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 1746152

Reaktionsgleichung

Reaktionsgleichung von HRID 1746152
F[C:2]1([N+:12]([O-:14])=[O:13])[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][CH2:3]1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:5]2[CH:4]=[CH:3][C:2]([N+:12]([O-:14])=[O:13])=[CH:7][C:6]=2[C:8]([F:11])([F:10])[F:9])[CH2:18][CH2:17]1

Komponenten

5

Edukt 2

HCID 531671-MethylpiperazineHCID 1317335435-Fluoro-5-nitrobenzotrifluoride

Produkt 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

5-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

Aufarbeitung

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c93388fe6f324de6bab8b8e47fdf79a8
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09149475B2

Verknüpfte Notizen

Wird geladen…