HCID 178525893, Verbindung → HCID 178525889, Verbindung
Reaktionsgleichung
Cl[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:11]=1)[S:8][C:7](=[O:19])[C:6]([C:20]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[O:21])=[C:5]2[OH:27]>[OH-].[Na+].[Pd]>[CH2:12]([C:10]1[CH:11]=[CH:2][CH:3]=[C:4]2[C:9]=1[S:8][C:7](=[O:19])[C:6]([C:20]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[O:21])=[C:5]2[OH:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
[(6-Chloro-4-hydroxy-2-oxo-8-benzyl-2H-thiochromene-3-carbonyl)-amino]-acetic acid (Example 42 a) (70 mg, 0.173 mmol) was dissolved in aqueous sodium hydroxide (870 uL 1M in 8 mL of water) and 10% palladium on carbon (7 mg) was added. The reaction was vacuum-purged and placed under an atmosphere of hydrogen gas and permitted to stir overnight at ambient temperature. Upon completion, the reaction was filtered through a pad of Celite® to remove the palladium catalyst. The product was precipitated with 1N HCl, isolated via filtration and dried to provide the title compound (30 mg.) MS ESI(−) m/e: 368.093 (M−1).