Benzene, 1-(1,1-dimethylethoxy)-2-nitro- → HCID 14763309, Verbindung

HRID 1747769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1747769
[C:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N+:12]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH2:12])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 1

HCID 10997909Benzene, 1-(1,1-dimethylethoxy)-2-nitro-

Produkt 1

HCID 14763309HCID 14763309, VerbindungAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-tert-butoxy-2-nitrobenzene (Journal of Organic Chemistry, 1998, 63, 25, 9495-9496.) (15.0 g) in methanol (300 mL) was added 10% palladium on carbon (1.67 g), and the mixture was stirred at room temperature for 30 hr under a hydrogen atmosphere. Palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (12.4 g).

Aufarbeitung

  1. customPalladium on carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-51075b9c336f441a9ed19910bd98ade2
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150588B2

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