Sulfuric Acid → HCID 86663613, Verbindung

HRID 1747862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1747862
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].S(=O)(=O)(O)[OH:18]>O>[F:16][C:2]1([F:1])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([NH2:13])=[O:18])=[CH:11][C:5]=2[O:4][C:3]1([F:14])[F:15]

Komponenten

4

Edukt 2

HCID 1118Sulfuric AcidHCID 27766192,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carbonitrile

Produkt 1

HCID 86663613HCID 86663613, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To 2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile (200 mg) were added concentrated sulfuric acid (2 mL) and water (0.3 mL) at room temperature. The reaction mixture was stirred at 40° C. for 3 hr, water was added and the mixture was stirred for 40 min at room temperature. The resulting solid was collected by filtration, washed with purified water, and dried under reduced pressure to give the title compound (190.6 mg).

Aufarbeitung

  1. stirringthe mixture was stirred for 40 min at room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with purified water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9f90c4b3013f405d84c49f06e735a90c
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150591B2

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