Hydrochloric Acid → 2-Methoxypyrrolo[1,2-b]pyridazine-6-carboxylic acid

Trimethyl 2-methoxypyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylate (1.84 g, 5.72 mmol) was suspended in a solution of potassium hydroxide (1.60 g, 28.6 mmol, 5 eq) in water (5 mL) and the mixture was heated to 60° C. for 1 h during which time all solids dissolved into a yellow solution. The solution was acidified with concentrated HCl (12 N, 5 mL) until pH=1 was achieved, and the mixture was heated to 90° C. overnight. The mixture was then cooled to RT and a dark solid was recovered by filtration. MS m/z 193.1 (M+1).

1. dissolutiondissolved into a yellow solution
2. temperaturethe mixture was heated to 90° C. overnight
3. temperatureThe mixture was then cooled to RT
4. filtrationa dark solid was recovered by filtration

ORD-Eintrag

ord-cd2c1a9035734e13b43a5acdf3ed0a3e

Quelldatensatz

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09150568B2