Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate → 5-Tert-butyl-1,3-oxazol-2-amine

HRID 1748331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1748331
[C:1]([C:5]1[O:9][C:8]([NH:10]C(=O)OCC2C=CC=CC=2)=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[O:9][C:8]([NH2:10])=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 14054539Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate

Produkt 1

HCID 146232945-Tert-butyl-1,3-oxazol-2-amineAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate (5.0 g, 18.2 mmol) in methanol (100 mL) is added 10% palladium on carbon (500 mg, 0.5 mmol). The reaction is stirred at room temperature for 3 h under hydrogen atmosphere. The reaction mixture is filtered through Celite and the filtrate is concentrated. The residue is purified by flash column chromatography to afford the title compound (1.7 g, 68%) as a light brown solid.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered through Celite
  2. concentrationthe filtrate is concentrated
  3. customThe residue is purified by flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c8351d8a8e604ec1911bc060e66eade0
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150577B2

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