Water → 1-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid

HRID 1748485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1748485
FC(F)(F)C(O)=O.C([O:12][C:13]([C:15]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][N:21]=2)[CH:16]=1)=[O:14])(C)(C)C.O>ClCCl>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([N:17]2[CH:18]=[CH:19][C:15]([C:13]([OH:14])=[O:12])=[CH:16]2)=[N:21][CH:22]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 866924471-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester

Produkt 1

HCID 866924481-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acidAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (3 ml) was added to a solution of 1-(5-chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester (1.0 g) in dichloromethane (10 ml) and stirred at room temperature for four hours. Water was added to the reaction solution and the precipitated solid was washed with water to give the titled compound (775 mg) as a gray solid.

Aufarbeitung

  1. washthe precipitated solid was washed with water

Quellen und Nachweise

ORD-Eintrag
ord-7bd8f627acfb4b40a3a5b55cea1781c8
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150555B2

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