Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde → 1-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

HRID 1748486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1748486
CO[CH:3]1[CH:7]([CH:8]=[O:9])[CH2:6][CH:5](OC)O1.Cl.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>O>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH:5]=[CH:6][C:7]([CH:8]=[O:9])=[CH:3]2)=[CH:17][CH:16]=1

Komponenten

4

Edukt 2

HCID 567310Tetrahydro-2,5-dimethoxyfuran-3-carbaldehydeHCID 27349564-Anisidine hydrochloride

Produkt 1

HCID 105599931-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2,5-Dimethoxytetrahydrofuran-3-carbaldehyde (7.31 g) and p-anisidine hydrochloride (7.28 g) were added to water (100 ml) and stirred at 60° C. for three hours. The precipitated yellow solid were filtered at the same temperature, washed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml) to give 1-(4-methoxyphenyl)pyrrole-3-carb aldehyde.

Aufarbeitung

  1. filtrationThe precipitated yellow solid were filtered at the same temperature
  2. washwashed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml)

Quellen und Nachweise

ORD-Eintrag
ord-88551588a76e48aaa70c5b1b9d121d31
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150555B2

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