HCID 86714433, Verbindung → HCID 86714432, Verbindung

HRID 1750222Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750222
[C:1]([O:5][C:6](=[O:31])[C@@H:7]([NH:12][C:13](=[O:30])[C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH:21]([CH3:26])[CH2:22][CH:23]([CH3:25])[CH3:24])=[C:16]([N+:27]([O-])=O)[CH:15]=1)[CH2:8][CH:9]([CH3:11])[CH3:10])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:31])[C@@H:7]([NH:12][C:13](=[O:30])[C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH:21]([CH3:26])[CH2:22][CH:23]([CH3:24])[CH3:25])=[C:16]([NH2:27])[CH:15]=1)[CH2:8][CH:9]([CH3:11])[CH3:10])([CH3:2])([CH3:4])[CH3:3]

Komponenten

4

Edukt 1

HCID 86714433HCID 86714433, Verbindung

Produkt 1

HCID 86714432HCID 86714432, VerbindungAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

50 mg of (S)-2-[4-(1,3-Dimethyl-butylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester were dissolved in 0.5 ml, ethanol, 5 mg of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 4 h. The catalyst was removed by filtration over celite, and the reaction mixture was concentrated to yield 45 mg (99%) of (S)-2-[3-Amino-4-(1,3-dimethyl-butylamino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester, which was used without further purification.

Aufarbeitung

  1. additionwere added
  2. customThe catalyst was removed by filtration over celite
  3. concentrationthe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-bcc7a1fa2b7543daac3845082ea5eee7
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156796B2

Notizen zur Reaktion

Wird geladen…