3-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester → HCID 86714449, Verbindung

HRID 1750241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750241
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]2[C:17]([F:20])([F:19])[F:18])=[C:6]([N+:21]([O-])=O)[CH:5]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]2[C:17]([F:20])([F:18])[F:19])=[C:6]([NH2:21])[CH:5]=1

Komponenten

4

Edukt 1

HCID 867144483-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester

Produkt 1

HCID 86714449HCID 86714449, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.63 g 3-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester were dissolved in 25 ml methanol, 0.03 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 16 h. The catalyst was removed by filtration over celite, the filtrate was concentrated to obtain 1.44 g (97%) of 3-Amino-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester.

Aufarbeitung

  1. customThe catalyst was removed by filtration over celite
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-eec625b33519442c8f260dde60b5deb7
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156796B2

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