Tert-butyl 2,2,2-trichloroethanimidate → Tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

HRID 1751771Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1751771
[C:1]([O:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Br:15])[CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].[C:16](OC(=N)C(Cl)(Cl)Cl)([CH3:19])([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:1]([O:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Br:15])[CH:10]=1)[C:6]([O:8][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:7])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 2734700Tert-butyl 2,2,2-trichloroethanimidateHCID 712121582-Acetoxy-2-(3-bromophenyl)acetic acid

Produkt 1

HCID 71229801Tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of compound 2 (500 mg, 1.83 mmol) in toluene (2.5 mL) was added t-butyl-trichloroacetimidate (0.33 mL). The reaction was stirred at room temperature for 5 hours. The solid precipitate was filtered off and washed with toluene. The filtrate was concentrated in vacuo to provide compound 3 which was used in the next reaction without further purification.

Aufarbeitung

  1. filtrationThe solid precipitate was filtered off
  2. washwashed with toluene
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-427ee3c634324aae8f0eeb5b7737308f
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09161924B2

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