Triphosgene → 1-Hydroxy-4-adamantyl chloroformate
Reaktionsgleichung
[C:1]12([OH:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH:4]3[OH:11])[CH2:2]1)[CH2:8]2.[Cl:13][C:14](Cl)([O:16]C(=O)OC(Cl)(Cl)Cl)Cl>N1C=CC=CC=1.C(Cl)Cl>[Cl:13][C:14]([O:11][CH:4]1[CH:5]2[CH2:10][C:1]3([OH:12])[CH2:8][CH:7]([CH2:9][CH:3]1[CH2:2]3)[CH2:6]2)=[O:16]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 1,4-adamantanediol (210 mg, 1.25 mmol) in dry pyridine (3 mL) and dry CH2Cl2 (6 mL) was cooled in an ice bath and a solution of triphosgene (122 mg, 0.41 mmol) in dry Ch2Cl2 (3 mL) was added dropwise over 5 min. The mixture was stirred in the ice bath for 3 h to afford a 0.1 M solution of 1-hydroxy-4-adamantyl chloroformate.
Quellen und Nachweise
- ORD-Eintrag
- ord-08dce3b9c49c4bf7b2f13c4f1e925941
- Quelldatensatz
- uspto-grants-2015_10
- Patentnummer
- US09163012B2
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