Ethyl orthoformate → Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
Reaktionsgleichung
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:13]([O:15][CH:16](OCC)OCC)[CH3:14]>C(OC(=O)C)(=O)C>[CH2:13]([O:15]/[CH:16]=[C:4](/[C:3](=[O:10])[C:2]([F:11])([F:12])[F:1])\[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:14]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of ethyl 4,4,4-trifluoro-3-oxobutanoate (20 g, 108.63 mmol) in acetic anhydride (39 mL) was added triethylorthoformate (54.2 mL, 325.89 mmol) and the reaction heated to reflux for 18 hours. The reaction was cooled, concentrated in vacuo and used directly in the next step.
Aufarbeitung
- temperaturethe reaction heated
- temperatureto reflux for 18 hours
- temperatureThe reaction was cooled
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-c4d1ba12b2db4c698f4e8d65ad4744ba
- Quelldatensatz
- uspto-grants-2015_10
- Patentnummer
- US09163021B2
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