4-Pyrrolidinopyridine → 4-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

HRID 1753805

Reaktionsgleichung

Reaktionsgleichung von HRID 1753805
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[N:10]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

Komponenten

4

Edukt 2

HCID 755674-PyrrolidinopyridineHCID 2472224-Chloro-6-hydrazinylpyrimidine

Produkt 1

HCID 596037004-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2.0 g (13.8 mmol) of the compound from Example 7A and 4.3 g (27.7 mmol) 4-pyrrolidin-1-ylpyridine is stirred in 20 ml water at 100° C. for 16 h. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

Aufarbeitung

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. washwashed first with ethanol
  4. dry with materialwith diethyl ether and dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a5d3caab4cc24a7aae1f6c16ab355b33
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09168249B2

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