Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene

HRID 1754059

Reaktionsgleichung

Reaktionsgleichung von HRID 1754059
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropane

Produkt 1

HCID 156257521-Bromo-4-(cyclopropylmethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried over MgSO4 and the solvent is removed in vacuo.

Aufarbeitung

  1. extractionextracted with DCM
  2. dry with materialThe organic layer is dried over MgSO4
  3. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c5898888703d450b96cc0836bd4c9444
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09169205B2

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