(R)-tert-butyl 4,4-difluoro-2-(4-methyl-2-oxopent-3-enyl)pyrrolidine-1-carboxylate → 1-((R)-4,4-difluoropyrrolidin-2-yl)-4-methylpent-3-en-2-one

HRID 1754404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1754404
[F:1][C:2]1([F:21])[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([CH2:14][C:15](=[O:20])[CH:16]=[C:17]([CH3:19])[CH3:18])[CH2:3]1>C(O)=O>[F:21][C:2]1([F:1])[CH2:6][NH:5][C@H:4]([CH2:14][C:15](=[O:20])[CH:16]=[C:17]([CH3:18])[CH3:19])[CH2:3]1

Komponenten

3

Edukt 1

HCID 86704458(R)-tert-butyl 4,4-difluoro-2-(4-methyl-2-oxopent-3-enyl)pyrrolidine-1-carboxylate

Produkt 1

HCID 867044601-((R)-4,4-difluoropyrrolidin-2-yl)-4-methylpent-3-en-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A HCO2H (20 ml) solution of (R)-tert-butyl 4,4-difluoro-2-(4-methyl-2-oxopent-3-enyl)pyrrolidine-1-carboxylate (1.10 g, 3.6 mmol) was stirred at room temperature for 6 hours until only trace amount of SM was detected by LC-MS. Solvent was removed in vacuo with bath temperature ≦23° C. Compound 1-((R)-4,4-difluoropyrrolidin-2-yl)-4-methylpent-3-en-2-one was obtained as a light brown oil and was used directly in next reaction.

Aufarbeitung

  1. customSolvent was removed in vacuo with bath temperature ≦23° C

Quellen und Nachweise

ORD-Eintrag
ord-e614f76b38f749c6a74c965726fdeb77
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09169249B2

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