Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide

HRID 17546

Reaktionsgleichung

Reaktionsgleichung von HRID 17546
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 679824-Fluoro-2-methylaniline

Produkt 1

HCID 2737623N-(4-Fluoro-2-methylphenyl)acetamideAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.

Aufarbeitung

  1. customThe solidified reaction mixture
  2. washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated away under reduced pressure
  5. customthe residue was dried with a vacuum pump

Quellen und Nachweise

ORD-Eintrag
ord-b28a3fb55f434213817c419a6f86b40a
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737166B2

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