Hydrochloric Acid → HCID 178432397, Verbindung

HRID 1755883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1755883
[SH:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=[C:4]([C:12]([O:14]C)=O)[CH:3]=1.[NH2:16][OH:17].Cl>CO>[OH:17][NH:16][C:12]([C:4]1[CH:3]=[C:2]([SH:1])[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=1)=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 178498634HCID 178498634, Verbindung

Produkt 1

HCID 178432397HCID 178432397, VerbindungAusbeute 107,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 7-mercapto-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxylate (500 mg) (2.23 mmol) are suspended in 100 ml of absolute methanol. 2.95 mg (8.9 mmol) of hydroxylamine are added within 4 days while stirring. The reaction mixture is acidified (pH 6) with 3N aqueous hydrochloric acid. The product is filtered off under suction and washed in succession with water, methanol and diethyl ether. There are obtained 540 mg of N-hydroxy-7-mercapto-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxamide as yellow crystals of melting point 178°-179° C.

Aufarbeitung

  1. filtrationThe product is filtered off under suction
  2. washwashed in succession with water, methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-86b72fd49362429bb0d7ecf901dbddb4
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05438052

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