4-Toluenesulfonyl chloride → 2,3-Dihydro-4-[(4-methylphenyl)sulfonyloximino]-2-phenyl-4H-1-benzopyran

HRID 1757952

Reaktionsgleichung

Reaktionsgleichung von HRID 1757952
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[OH:12][N:13]=[C:14]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:15]1>N1C=CC=CC=1>[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([O:12][N:13]=[C:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH:16]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:15]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 73974-Toluenesulfonyl chlorideHCID 2483142,3-Dihydro-4-(hydroxyimino)-2-phenyl-4H-1-benzopyran

Produkt 1

HCID 2483152,3-Dihydro-4-[(4-methylphenyl)sulfonyloximino]-2-phenyl-4H-1-benzopyran

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel2×

Versuchsvorschrift

A solution of p-toluenesulfonyl chloride (83 g) in 125 ml pyridine was added dropwise at 5°-10° to 2,3-dihydro-4-(hydroxyimino)-2-phenyl-4H-1-benzopyran (52 g) in 230 ml pyridine. The reaction mixture was then stirred for 20 hours at room temperature, poured into ice-water to separate out the title compound, which was filtered, washed several times with water, then once with ether, and finally dried in air. Yield: 85.5 g; m.p. 141°-143°.

Aufarbeitung

  1. customto separate out the title compound, which
  2. filtrationwas filtered
  3. washwashed several times with water
  4. dry with materialonce with ether, and finally dried in air

Quellen und Nachweise

ORD-Eintrag
ord-67ef42dec5da44098a97b2815a83acfe
Quelldatensatz
uspto-grants-1983_02
Patentnummer
US04371541

Verknüpfte Notizen

Wird geladen…