Ethylene Glycol → HCID 54259475, Verbindung

HRID 1758263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1758263
[CH:1]([CH:4]([C:7]1[CH:15]=[CH:14][C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=1)[C:5]#N)([CH3:3])[CH3:2].[OH-:16].[K+].C(O)C[OH:20]>O>[CH:1]([CH:4]([C:7]1[CH:15]=[CH:14][C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=1)[C:5]([OH:20])=[O:16])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 54066355HCID 54066355, Verbindung

Produkt 1

HCID 54259475HCID 54259475, VerbindungAusbeute 50,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

A mixture of α-isopropylbenzofuran-6-acetonitrile (1.62 g, 0.008 mol), potassium hydroxide (2.29 g, 0.039 mol), ethane-1,2-diol (28 cm3) and water (2.3 cm3) was refluxed at 140° C. for 18 hr. The cooled mixture was poured into water and extracted with diethyl ether. The aqueous solution was acidified with hydrochloric acid and the mixture was extracted with diethyl ether. The ether extract was washed with water, dried (Na2SO4), filtered and the solvent was removed to give α-isopropylbenzofuran-6-acetic acid (0.90 g, 0.0041 mol, 50.8%). Recrystallised from petroleum ether (b.p. 60°-80° C.) m.p. 99°-100° C. (Found: C, 71.52; H, 6.65; C13H14O3 requires C, 71.54; H, 6.47%), t.l.c./silica/ethyl acetate RF 0.40.

Aufarbeitung

  1. extractionextracted with diethyl ether
  2. extractionthe mixture was extracted with diethyl ether
  3. extractionThe ether extract
  4. washwas washed with water
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-4c00e3c704d840b78106dd02db71ab06
Quelldatensatz
uspto-grants-1983_02
Patentnummer
US04372970

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