Formaldehyde → N-Methyl-1-Deoxynojirimycin

HRID 1759247Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1759247
[CH2:1]([OH:12])[C@H:2]1[NH:7][CH:6](O)[C@H:5]([OH:9])[C@@H:4]([OH:10])[C@@H:3]1[OH:11].[CH2:13]=O>O.[Pt]>[CH3:13][N:7]1[C@H:2]([CH2:1][OH:12])[C@@H:3]([OH:11])[C@H:4]([OH:10])[C@@H:5]([OH:9])[CH2:6]1

Komponenten

5

Edukt 2

HCID 712FormaldehydeHCID 65242(3R,4S,5R,6R)-6-(Hydroxymethyl)-2,3,4,5-piperidinetetrol

Produkt 1

HCID 92381N-Methyl-1-DeoxynojirimycinAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

179 mg of nojirimycin is dissolved in 20 ml of water, followed by adding 1 ml of formalin, adding 100 mg of platinum on carbon catalyst and carrying out a catalytic reduction at ordinary temperature and under atmospheric pressure. The following treatments are carried out in the same manner as in Example 2 to obtain 150 mg (85%) of N-methyl moranoline.

Quellen und Nachweise

ORD-Eintrag
ord-9484f7600e0a41e3a0572fd586ec3f9e
Quelldatensatz
uspto-grants-1982_07
Patentnummer
US04339585

Notizen zur Reaktion

Wird geladen…