Water → 4-Hydroxyethyl-5-methyl-2-phenylimidazole

HRID 1760489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1760489
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12])=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[OH:3][CH2:4][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12]

Komponenten

5

Edukt 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

Produkt 1

HCID 543635624-Hydroxyethyl-5-methyl-2-phenylimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

A solution of 4-ethoxycarbonylmethyl-5-methyl-2-phenylimidazole (19.7 g) in tetrahydrofuran (100 ml) was added dropwise (in 45 min) to lithium aluminium hydride (10 g) in tetrahydrofuran (150 ml). After 2 h refluxing the reaction mixture was allowed to stand overnight at r.t. It was cooled in an ice bath and water (40 ml) and tetrahydrofuran (50 ml) were added. The solids were filtered off and washed with diethylether.

Aufarbeitung

  1. temperatureAfter 2 h refluxing the reaction mixture
  2. temperatureIt was cooled in an ice bath
  3. filtrationThe solids were filtered off
  4. washwashed with diethylether

Quellen und Nachweise

ORD-Eintrag
ord-8a360cf9f533446187ab97dca9eb016c
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06841553B2

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