Water → (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone

HRID 1761260

Reaktionsgleichung

Reaktionsgleichung von HRID 1761260
Cl.[CH2:2]([C:6]1[O:7][C:8]2[CH:35]=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][C:9]=2[C:10]=1[C:11](=[O:31])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:23][CH2:24][CH2:25][CH3:26])=[CH:14][CH:13]=1)[CH2:3][CH2:4][CH3:5].O>C(=O)([O-])O.[Na+]>[CH2:2]([C:6]1[O:7][C:8]2[CH:35]=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][C:9]=2[C:10]=1[C:11](=[O:31])[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:23][CH2:24][CH2:25][CH3:26])=[CH:16][CH:17]=1)[CH2:3][CH2:4][CH3:5]

Komponenten

4

Edukt 2

HCID 962WaterHCID 10209257(2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone hydrochloride

Produkt 1

HCID 10209258(2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

The organic phase, comprising the 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitrobenzofuran hydrochloride thus formed, is subsequently washed 5 times using 600 ml of deionized water. It is washed a sixth time with 600 ml of deionized water comprising 50 g (0.595 mol) of sodium hydrogencarbonate to release the desired compound. The chlorobenzene is removed on a rotary evaporator (bath temperature: 35° C., pressure: 10 mmHg).

Aufarbeitung

  1. customthus formed
  2. washis subsequently washed 5 times

Quellen und Nachweise

ORD-Eintrag
ord-326989a28fe44b1c90a5059f023b1277
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06846936B2

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