Potassium Permanganate → 5-Cyano-6-methoxypicolinic acid
Reaktionsgleichung
[C:1]([C:3]1[C:4]([O:10][CH3:11])=[N:5]C(C)=[CH:7][CH:8]=1)#[N:2].[Mn]([O-])(=O)(=O)=O.[K+].[CH:18]([OH:21])([CH3:20])C.[OH2:22].Cl>>[C:1]([C:3]1[CH:8]=[CH:7][C:20]([C:18]([OH:21])=[O:22])=[N:5][C:4]=1[O:10][CH3:11])#[N:2]Komponenten
4
Versuchsvorschrift
3-Cyano-2-methoxy-6-methylpyridine is oxidised with potassium permanganate in aqueous solution to give 5-cyano-6-methoxypyridine-2-carboxylic acid (m.p. 235°-237° C.), subsequent hydrogenation of which on palladium/charcoal in isopropanol/water/hydrochloric acid gives the desired compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-265e4db7ac3141999db4c614009fc41b
- Quelldatensatz
- uspto-grants-1989_05
- Patentnummer
- US04826858
Notizen zur Reaktion
Wird geladen…