Ethyl 3-(benzylamino)-3-methylbutanoate → 4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Ethyl 3-(benzylamino)-3-methylbutanoate	HCID 288946	—
Edukt	Ethyl 4-(chloroacetyl)-7-hydroxy-1H-indole-2-carboxylate	HCID 13243454	—
Produkt	4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride	HCID 70381467	15,9%

Reaktionsschritte

Under the conditions of Example 28, 2.57 g of 4-chloroacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester is reacted with 2.35 g of 3-benzylamino-3-methylbutyric acid ethyl ester and worked up, yielding 0.75 g of 4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride, decomposition point 210°-212° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04835175
Quelldatensatz	uspto-grants-1989_05
ORD ID	ord-97730f51818f4c69874a30141c7f4ad7
Quellennotiz	uspto-grants-1989_05