Aluminum(III) Chloride → HCID 20309528, Verbindung

HRID 1763313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763313
[CH3:1][NH:2][C:3](=[O:18])[CH2:4][CH2:5][C:6](=[O:17])[C:7]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=1[O:15]C.[Cl-].[Al+3].[Cl-].[Cl-]>ClC1C=CC=CC=1>[CH3:1][NH:2][C:3](=[O:18])[CH2:4][CH2:5][C:6](=[O:17])[C:7]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=1[OH:15]

Komponenten

4

Edukt 2

HCID 6451240Aluminum(III) ChlorideHCID 20309506HCID 20309506, Verbindung

Produkt 1

HCID 20309528HCID 20309528, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7964ChlorobenzeneLösungsmittel

Versuchsvorschrift

N-Methyl 3-(2,6-dimethoxybenzoyl)propionamide was demethylated with aluminium chloride in chlorobenzene to give N-methyl 3-(2-hydroxy-6-methoxybenzoyl)propionamide, m.p. 125° which may also be prepared from a by-product, N-methyl 3-(2,6-dihydroxybenzoyl)propionamide, by selective methylation with methyl iodide and potassium carbonate in acetone. (iii) By subjecting N-methyl 3-(2-hydroxy-6-methoxybenzoyl)-propionamide to a series of reactions similar to those described in Examples 1(i-ii) and 2(i-v), the title compound may be prepared.

Quellen und Nachweise

ORD-Eintrag
ord-fe645e36123b414187ba1e7960efccd6
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04111936

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