Hydrochloric Acid → L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

HRID 1763725Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763725
[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH:11]C(OCC1C=CC=CC=1)=O.CO.[ClH:47]>[Pd].O1CCCC1>[ClH:47].[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:38]=[CH:39][C:40]([OH:43])=[CH:41][CH:42]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH2:11]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54186548HCID 54186548, Verbindung

Produkt 1

HCID 70617527L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a mixture of 3.1 g. of Nα -benzyloxycarbonyl-L-trytophyl-L-seryl-L-tyrosine methyl ester and 200 mg. of 20% palladium on carbon is added 75 ml. of methanol containing 1.7 ml. of 3N hydrogen chloride in tetrahydrofuran and the reaction is stirred under an atmosphere of hydrogen for two and a half hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated under reduced pressure to give a residue of L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

Aufarbeitung

  1. additionTo a mixture of 3.1 g
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ff3903e65c1846ec828462fa69a4cdc2
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04111923

Notizen zur Reaktion

Wird geladen…